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Changes in Coagulation Profile in Dengue Patients with Hepatitis Attending to a Tertiary Care Hospital in Sri Lanka

Dengue is a fast-growing global issue, which is endemic in Sri Lanka. Changes in coagulation is thought to contribute to complications of dengue but the evidence is lacking.

Objective: To assess the changes in coagulation profile in patients with dengue, with or without hepatitis in a tertiary care hospital, in Sri Lanka.

Method: A cross sectional survey was carried out in patients with dengue (n=139) in Sri Jayewardenepura General Hospital with confirmed dengue, in 2013.

Results: There was no statistically significant difference when either the APTT or PT result, compared with more than two-fold rise in aspartate aminotransferase level during the course of illness (p>0.05).

Conclusion: Presence of hepatitis was not predictive of abnormal APTT/PT values. Further larger scaled studies are recommended in achieving conclusions.

Author(s): Champika Gamakaranage, Chamani Gamakaranage and Ravindra L Satharasinghe

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