Identification to Species Level of Candida parapsilosis Complex into Sites Oral Cavity in a Cohort of Argentinos Patients

Candida parapsilosis is a complex of three species (Cp. sensu stricto, Candida orthopsilosis and Candida methapsilosis) due to genetic heterogeneity. Currently, it is the second most isolated in yeast bloodstream infections in Latin America, Asia and Europe. In Argentina and globally is no data on the distribution and behavior of the species that make up this complex in oral niches. Knowledge becomes important in the event that the mouth can be a potential source of candidemia and / or invasive infections by this yeast in patients with other risk factors source. Objective: To identify to species C. parapsilosis complex in clinical isolates obtained from various oral niches, of a cohort of Argentinos patients with different bucodentarias clinical situations. Methods: Retrospective, transversal and descriptive study using 31 clinical isolates of oral cavity, cryopreserved and obtained from immunocompetent patients with and without periodontal disease, and presence or absence of intraoral appliances; previously recognized by conventional methods such as C. parapsilosis, and recovered for molecular characterization endpoint PCR using specific primers. Results: 100% (31/31) of the isolates were positive for Candida parapsilosis sensu stricto. 77.5% of these strains were recovered in oral inflammatory conditions, and 22.5% in terms of oral health. Being statistically significant difference (p=0). Conclusions: C. parapsilosis sensu stricto is a common colonizing the oral mucosa, especially in pathological conditions.

Author(s):

Rodrígue L, Rosa A and Jewtuchowicz V

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