Abstract

Objective: To investigate the risk factors and drug-resistance of Escherichia coli in patients with Biliary Tract Infections (BTIs). In addition, prognostic factors related to survival in patients with BTI were evaluated. Methods: A retrospective observational study was performed to analyze the relationship between antimicrobial use and bacterial resistance. Results: Biliary tract infection caused by E. coli was diagnosed in 0.81% of patients from general surgery (107 of 13163) admitted to the hospital between January 1, 2012 and December 31, 2014. Of the 107 isolates, 102 (95.3%) were resistant to at least one antimicrobial agent and 86.9% (93/107) to two or more antibiotics. 80.4% were resistant to piperacillin, 27.1% to piperacillin/tazobactam, 61.7% to cefuroxime, 57% to cefoxitin, 48.6% to cefotaxime, 43.9% to ceftazidime, 38.3% to cefepime, 44.8% to levofloxacin. However, all strains were susceptible to imipenem. The detection rates of ESBLs-producing Escherichia coli were 41.1%. Conclusion: Prior receipt of antimicrobial therapy was significantly associated with infection caused by resistant organism and most strains were resistant to multiple antimicrobial agents.